Anti-Inflammatory and Neuroprotective Effect of the Anti-Obesity Dietary Supplement Dekosilhue® in an In Vitro Model of Neuroinflammation

Obesity is now recognized as a global health problem and has reached epidemic proportions, affecting both developed developing countries. This condition associated with an increased incidence in central nervous system (CNS) disorders. The intake of foods or supplements anti-inflammatory activity could potentially lead to lower impact obesity on the functionality CNS. Therefore, this work we tested effect dietary supplement, DEKOSILHUE® (DSK), containing polyphenols enriched herbal extracts successfully used for improving control body weight, vitro inflammatory model. LPS-stimulated immortalized microglia BV2 cells have been model neuroinflammation. stimulation LPS release activation several neuroinflammatory mediators, such IKB⍺, HDAC-1, IL-1ß. DSK reduced levels all these pro-inflammatory markers. In addition, expression cytokine IL-10, promoting response. Finally, showed that can prevent neurotoxicity related hyperactivation. conclusion, help controlling neuroinflammation CNS, reducing activation.